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TGF--g(b)1/-g(b)2: A NOVEL CHIMERIC TRANSFORMING GROWTH FACTOR-BETA.
TGF--g(b)1/-g(b)2: A NOVEL CHIMERIC TRANSFORMING GROWTH FACTOR-BETA.
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机译:TGF-g(b)1 / -g(b)2:一种新型的嵌合转化生长因子-贝塔。
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摘要
The present invention relates to the production of large quantities of a novel chimeric TGF-(beta), termed TGF-(beta)1/(beta)2, by eucaryotic host cells transfected with recombinant DNA vectors containing the TGF-(beta)1/(beta)2 precursor coding sequence controlled by expression regulatory elements. Simian TGF-(beta)1 cDNA (Sharples et al., 1987, DNA 6:239-244) was modified so that the nucleotides encoding amino acid residue numbers 9-13, 17, 19, 25 and 26 of the mature TGF-(beta)1 sequence were hanged to the nucleotides encoding the corresponding amino acids of the mature TGF-(beta)2 structure. Simian codon usage was maintained. The chimeric TGF-(beta)1/(beta)2 of the invention induces effects on the proliferation of vascular endothelial cells equivalent to those induced by TGF-(beta)1.
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