Synthetic polypeptides derived from the human immunodeficiency virus (HIV) surface glycoprotein (HIV envelope glycoprotein)

摘要

The present invention relates to a synthetic polypeptide having one or more antigenic properties of the surface protein of one or more human immunodeficiency virus (HIV) strains, wherein the polypeptide is substantially the amino acid sequence X-R of the general formula (I)_One-Leu-R₂-Leu-Thr-Val-Trp-Gly-R₃-Lys-Y (I): wherein R_One RTI ID = 0.0 Gln-Gln-R₄-R₅, Gln-R₄-R₅, R₄-R₅Or R₅; R₂Is an amino acid residue selected from Gly, Lys, Glu, or Arg; R₃Is an amino acid residue selected from Ile, Thr or Ala; R₄Is His or GIu; R₅Is Leu or Met; X and Y are each independently absent or independently may be one or more amino acid residues. Preferred peptides are of the general formula (Ia); Leu-Gln-Leu-Thr-Val-Trp-Gly-Ile-Lys-Y: Gly-Ile-Lys-Y; Gly-Thr-Lys-Y; X-Gln-Gln-Glu-Met-Leu-Arg-Leu-Thr-Val-Trp-Gly-Thr-Lys-Y; Lys-Y, preferably X is absent and Y is Gly-Cys or Gly-Cys-Ala. Desc / Clms Page number 12 These peptides are similar to certain epitopes of HIV surface proteins.