Human hepatocarcinoma cell line expressing multiple drug resistance 1 gene and hepatitis B virus (HBV) gene

摘要

The present invention relates to a human hepatoma cell line SNU-354 or SNU-368 which expresses highly hepatitis B virus (HBV) gene with high expression of multidrug resistance-1 gene (MDR1) Since the expression of the drug resistance-related protein is very high, resistant to doxorubicin, resistant to the drug-resistant reversal drug, and has a characteristic of strongly expressing the HBV gene, the drug resistance and hepatocellular carcinoma It is useful for the development of therapeutic agents.