A monoclonal antibody recognizing FK506-binding protein, a method for analyzing the concentration of FK506-binding protein, and a kit therefor (MONOCLONAL ANTIBODY RECOGNIZING FK506-BINDING PROTEIN, METHOD FOR ASSAYING FK506-BINDING PROTEIN LEVEL, AND KIT THEREFOR)

摘要

The present invention relates to a monoclonal antibody (anti-FKBP antibody) which recognizes an antigenic crystal group in FK506-binding protein but does not inhibit binding between FK506-binding protein and FK506; A method of analyzing FKBP concentration in plasma by reacting immobilized anti-FKBP antibody, enzyme-labeled FK506 and FKBP in a sample and analyzing the color development degree of the enzyme substrate; And an assay kit.;According to the present invention, it is possible to easily and more accurately analyze the concentration of FKBP in plasma, which influences the immunosuppressive action of FK506, and thus it becomes possible to determine the optimal dose of FK506 more suited to the conditions of individual patients.