METHOD OF SYNTHESIS OF 3-(1-THIAZOLIDINYLBUTYL-4-PIPERAZINYL)-1H-INDAZOLES

摘要

FIELD: organic chemistry. SUBSTANCE: product: 3-(1-thiazolidinylbutyl-4-piperazinyl)-1H-indazoles of the general formula (I) where R₁ and R₂ independently each of other hydrogen, lower alkyl or R₁ and R₂ together with carbon to which they are bound form cyclopentane or cyclohexane ring; R₃ and R₄ independently each of other hydrogen or lower alkyl; R₅ hydrogen or lower alkyl; X hydrogen or halogen, or their pharmaceutically acid-additive salts. Reagent 1: derivative of 4-thiazolodinone of the formula (II) where R₁, R₂, R₃ and R₄ as indicated above. Reagent 2: 3-(1-piperazinyl)-1H-indazole of the formula (III) where X as indicated above. Reaction conditions: in the medium of organic solvent, at heating in atmosphere of inert gas. In the case of synthesis of compounds where R₅ lower alkyl compound of the formula (I) where R₃ hydrogen is alkylated. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl