preparations and processes for clones, with the mehrfacharzneimittelresistenz associated dna sequences in human cells.

摘要

Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrugresistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.