Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivoand as Directed by Cloned Cholinesterase DNA Sequences

摘要

Acetylcholinesterase (ACHE) is an enzyme long noted for its essential role in thetermination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase (BCHE), it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis.