Chromatographic support material and its use in a method for the chromatographic separation of nucleic acids

摘要

A chromatographic carrier has cavities that are one to twenty times larger than the largest dimensions of the nucleic acids to be separated. This carrier is produced by reacting a base carrier material with cavities between 10 and 1000 nm, a specific surface between 5 and 800 m?2/g and a grain size between 3 and 500 $g(m)m with a silanating reagent that has at least one reagent group already reacted with a primary or secondary hydroxyalkylamine or a reagent group capable of being reacted with an hydroxyalkylamine, such as an epoxide group or halogen atoms, which are reacted with an hydroxyalkylamine at a later reaction stage.