Method of synthesis of acycles derivatives of fatty acid-transporting thiols, in particular of the acyl - coenzyme a, and the coenzyme acyl - is thus obtained .

摘要

The invention relates to a process for the synthesis of acylated derivative of a fatty acid-transporting thiol such as the coenzyme a. & br / according to this process, a thiol silyl or stannylated by reaction of the thiol with a silylation reagent or stannylation for at least partly replace the unstable hydrogens of the thiol groups sir3 or snr3 with r being an alkyl or aryl group. It is then reacted with the thiol silyl or stannylated, anhydrous organic medium, with an organic acid activated and a deprotection reagent capable of eliminating the silyl or stannyl groups. & br / it is thus possible to obtain the acylated derivatives of the coenzyme a in which the acyl group may have up to 30 carbon atoms, with high yields.