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Process for preparation of bevantolol hydrochloride
Process for preparation of bevantolol hydrochloride
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机译:盐酸贝伐洛尔的制备方法
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摘要
Disclosed is a new process for preparing bevantolol hydrochloride suitable for industrial production in which bevantolol hydrochloride can be obtained in a high yield and HVA of an expensive material can be recovered. The process for the preparation of bevantolol hydrochloride comprises the steps of: causing 3-(m-tolyloxy)-1,2- epoxypropane (TOEP) to react with &bgr;-(3,4-dimethoxyphenyl)ethylamine (HVA) of excess mole per mole of said TOEP; dissolving the reaction mixture in a halogenated hydrocarbon to give a solution; mixing the solution with hydrochloric acid; separating an organic layer from the resulting mixture; and obtaining 1-[(3,4-dimethoxyphenethyl)amino]-3-(m- tolyloxy)-2-propanol hydrochloride from the organic layer.
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