PROCESS FOR PREPARATION OF BEVANTOLOL HYDROCHLORIDE

摘要

A novel process for producing bevantolol hydrochloride suitable for industrial production is disclosed, in which bevantolol hydrochloride can be obtained in high yield and an expensive raw material HVA can be recovered. The method for preparing bevantolol hydrochloride includes 3- (m-tolyloxy) -1,2-epoxypropane (TOEP) with an excess mole of β- (3,4-dimethoxyphenyl) ethylamine (HVA) per mole of TOEP. React; The reaction mixture is dissolved in a halogenated hydrocarbon to give a solvent; This solution is mixed with hydrochloric acid; Separating the organic layer from the obtained mixture; This step consists in obtaining 1-[(3,4-dimethoxyphenethyl) amino] -3 (m-tolyloxy) -2-propanol hydrochloride from this organic layer.