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Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers
Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers
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机译:钙调蛋白介导的酶抑制剂的合成,包括KS-501,KS-502及其对映异构体
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摘要
The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent- KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.
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