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Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

机译：包括最近批准的非典型抗精神病药的二氯苯基哌嗪是DHCR7的有效抑制剂，胆固醇生物合成中的最后一酶

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Thiago C. Genaro-Mattos; Keri A. Tallman; Luke B. Allen; Allison Anderson; Karoly Mirnics; Zeljka Korade; Ned A. Porter;
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1. Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis [J] . Genaro-Mattos Thiago C., Tallman Keri A., Allen Luke B., Toxicology and Applied Pharmacology . 2018,第期

机译：二氯苯哌嗪，包括最近批准的非典型抗精神病药，是DHCR7的有效抑制剂，胆固醇生物合成中的最后一种酶
2. Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis. [J] . Abe I, Seki T, Noguchi H, Planta medica: Natural products and medicinal plant research . 2000,第8期

机译：大黄的没食子酸酯是角鲨烯环氧酶的有效抑制剂，角鲨烯环氧酶是胆固醇生物合成中的关键酶。
3. Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis [J] . Arbo Marcelo Dutra, Melega Simone, Stoeber Regina, Archives of Toxicology . 2016,第12期

机译：哌嗪设计药物的肝毒性：胆固醇和脂质生物合成关键酶的上调
4. Prevention of cholesterol gallstones by the potent cholesterol absorption inhibitor ezetimibe in gallstone-susceptible C57L/J mice [C] . H. H. WANG, P. PORTINCASA, D. Q.-H. WAN International Bile Acid Meeting . 2007

机译：通过胆结石易感C57L / J小鼠的有效胆固醇吸收抑制剂Ezetimibe预防胆固醇胆结石
5. Discovery and characterization of potent and selective inhibitors against the PEA-hydrolyzing enzyme, N-acylethanolamine-hydrolyzing acid amidase. [D] . Solorzano Say, Carlos Efrain. 2010

机译：发现和表征针对PEA水解酶，N-酰基乙醇胺水解酸酰胺酶的有效和选择性抑制剂。
6. Dichlorophenyl piperazines including a recently-approved atypical antipsychotic are potent inhibitors of DHCR7 the last enzyme in cholesterol biosynthesis [O] . Thiago C. Genaro-Mattos, Keri A. Tallman, Luke B. Allen, -1

机译：二氯苯基哌嗪类药物包括最近批准的非典型抗精神病药是DHCR7的有效抑制剂DHCR7是胆固醇生物合成中的最后一种酶
7. 5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons. [O] . Schroepfer, G J, Parish, E J, Kisic, A, 1982

机译：5 alpha-Cholest-8（14）-en-3 beta-ol-15-one，一种有效的甾醇生物合成抑制剂，可降低血清胆固醇，并改变狒狒脂蛋白中胆固醇的分布。

Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

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