Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor

摘要

Hybridomas producing monoclonal antibodies that specifically bind to the human EGF receptor and compete with EGF for binding to the EGF receptor are described. The subject monoclonal antibodies bind to an epitope located between residues Ala-351 and Asp-364 of the EGF receptor, which is not denatured by boiling, treatment with detergent or treatment with a reducing agent.