Their use in bacterial adhesion prevention fibronectin-binding proteins, monoclonal antibodies and

摘要

PCT No. PCT/GB94/00215 Sec. 371 Date Aug. 3, 1995 Sec. 102(e) Date Aug. 3, 1995 PCT Filed Feb. 4, 1994 PCT Pub. No. WO94/18327 PCT Pub. Date Aug. 18, 1994A monoclonal antibody (Mab), or a fragment thereof, that binds to one or more epitopes of a matrix binding protein and an isolated D1-D4 polypeptide from a Staphylococcus aureus Fbp and their use in the prevention of adhesion of bacteria, in particular gram positive bacteria, to extracellular matrix proteins on in-dwelling devices or to matrix proteins in wounds.