DIASTEREOSELECTIVE SYNTHESIS METHOD OF OPTICALLY ACTIVE CIS-NUCLEOSIDES, THEIR ANALOGS AND DERIVATIVES, AS WELL AS INTERMEDIATES EMPLOYED IN THE PROPOSED METHOD

摘要

A process for the diastereoselective synthesis of optically active cis nucleosides and analogs and derivatives thereof of formula (I), wherein W is O, S, S, S, S, S or methylene; X is O, S, sulfinyl, sulfonyl, NZ, methylene or CHF, CH, CHN3 or CHOH; Y is O, S, CH3 or CH, CHF or CHOH; Z is hydrogen, hydroxy, alkyl, or acyl; R.sub.1 represents a hydrogen atom or an acyl group; and R.sub.2 represents a residue of the desired purine or pyrimidine base or an analogue or derivative thereof; wherein when Y is methylene and X is O, S, S or S, W is not O, S, S or S, by glycosylation of the desired purine or