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Covalently-modified bacterial polysaccharide / protein conjugate, process for their preparation and the composition comprising a polysaccharide / protein conjugate
Covalently-modified bacterial polysaccharide / protein conjugate, process for their preparation and the composition comprising a polysaccharide / protein conjugate
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机译:共价修饰的细菌多糖/蛋白质缀合物,其制备方法和包含多糖/蛋白质缀合物的组合物
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摘要
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.
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