Polysaccharides stable with the immunogenic protein and bacterial neutral polysaccharide, covalently bound - protein conjugates, pharmaceutical compositions comprising the conjugate and a method of producing the conjugate

摘要

Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides and conjugates.