CHELATING AGENTS OF THE TYPE XN1S1O1 FOR RADIOACTIVE ISOTOPES, METAL COMPLEXES THEREOF, AND THEIR USE IN DIAGNOSIS AND THERAPY

摘要

Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the general formula (I): M-L, in which M is a radioisotope of Tc or Re, and L is a ligand of general formula (II). Surprisingly, it has been found that the bifunctional chalcogenic-atom-discontinuous chelating agents described, and their coupling products with specifically enriching compounds, are eminently suitable for use in the production of radiodiagnostic or radiotherapeutic compounds.