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METHOD OF PREPARATION 2-SUBSTITUTED 4,6-DIALKOXYPYRIMIDINES
METHOD OF PREPARATION 2-SUBSTITUTED 4,6-DIALKOXYPYRIMIDINES
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机译:2-取代的4,6-二酮基嘧啶的制备方法
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摘要
A novel process for the preparation of 2-substituted 4,6-dialkoxypyrimidines is described, in which a cyanoimidate of the general formula …IMAGE… is subjected to a cyclization reaction with a hydrogen halide to give a halopyrimidine derivative, which is then converted with compounds of the formula… M-R3 or… …IMAGE… to give the end product of the general formula …IMAGE… where R1 and R2 are identical or different and denote a C1-C4-alkyl group, R3 denotes an R4-O- or R4-S- group or …IMAGE… group, in which R4 denotes a C1-C4-alkyl group and R5 denotes a hydrogen atom, a C1-C4-alkyl group or a phenyl group.
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