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Psoralen conjugated methylphosphonate oligonucleotides as therapeutic agents for chronic myelogenous leukemia
Psoralen conjugated methylphosphonate oligonucleotides as therapeutic agents for chronic myelogenous leukemia
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机译:补骨脂素缀合的甲基膦酸酯寡核苷酸作为慢性粒细胞性白血病的治疗剂
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摘要
Novel reagents which are useful for conjugating a psoralen moiety to an oligomer having at least one non-nucleotide monomeric unit are provided. Also provided are psoralen-conjugated oligomers. Psoralen-conjugated oligomers complementary to the abl gene or bcr/abl of chimeric mRNA are useful in decreasing expression of abl-associated tyrosine kinase and P210 protein.
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