IDENTIFICATION OF DNA-DAMAGING SUBSTANCES BY MEANS OF CELL LINES CAPABLE OF OVEREXPRESSING POLY(ADP-RIBOSE)-POLYMERASE

摘要

A DNA construct that contains a cDNA sequence for human poly(ADP-ribose)-polymerase is disclosed, as well as cell lines that contain this DNA construct and a process for identifying DNA-damaging substances by means of said cell lines that overexpress poly(ADP-ribose)-polymerase.