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IMMUNOTARGETING OF PLASMINOGEN ACTIVATORS TO THE PULMONARY ENDOTHELIUM
IMMUNOTARGETING OF PLASMINOGEN ACTIVATORS TO THE PULMONARY ENDOTHELIUM
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机译:纤溶酶原激活物对肺内皮的免疫靶向作用
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摘要
A multimolecular complex made up of a plasminogen activator conjugated to anti-ACE Mab 9B9 capable of delivering the plasminogen activator to the pulmonary endothelium is provided. Methods of using this complex to selectively deliver the plasminogen activator to the pulmonary endothelium to enhance fibrinolysis in the lungs of an animal are also provided. In addition, a method of prolonging the time a plasminogen activator is present in the circulation of an animal by conjugating the plasminogen activator to anti-ACE Mab 9B9 is also provided.
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机译:提供了由与能将纤溶酶原激活剂递送至肺内皮的抗ACE Mab 9B9缀合的纤溶酶原激活剂组成的多分子复合物。还提供了使用该复合物选择性地将纤溶酶原激活剂递送至肺内皮以增强动物肺中纤维蛋白溶解的方法。另外,还提供了通过使纤溶酶原激活物与抗ACE Mab 9B9缀合来延长纤溶酶原激活物在动物循环中存在的时间的方法。
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