Process for the preparation of glycine-conjugated bile acids and relative pharmaceutical compositions useful for treating hepatic insufficiency

摘要

A process for the preparation of glycine-conjugated bile acids as per general formula (I):        (I)   Y-NH-CH₂-COOHwherein Y is the acyl radical of a bile acid selected from the group consisting of ursodeoxycholic, chenodeoxycholic, lithocholic, 3α-7β-12α-tri-hydroxycholanic, 3α-7β-dihydroxy-12-ketocholanic, deoxycholic, dehydrocholic, iodeoxycholic, iocholic acids and relative compositions for hepatic insufficiency treatment, containing the abovesaid acids as active ingredients, in continuation with suitable excipients and/or diluents.