CLONED GENES WHICH ENCODE ELAM-1 AND FUSION PROTEINS THEREOF, THE PROTEIN PRODUCTS EXPRESSED THEREFROM, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF

摘要

The invention relates to cloned genes, or degenerate variants thereof, which encode endothelial-leukocyte adhesion molecule-1 (ELAM-1), or fragments thereof. Such fragments may be leukocyte or complement-binding. The invention also relates to cloned genes encoding fusion proteins comprising ELAM. The invention also relates to vectors containing the cloned genes of the invention, hosts transformed with the vectors, and the protein products expressed therefrom. The invention also relates to pharmaceutical compositions comprising the expressed proteins. The invention also relates to methods for the treatment of inflammation, post reperfusion injury, bacterial infections, vasculitis, leukemia, and methods of inhibiting metastatic spread of tumor cells by administering the pharmaceutical compositions of the invention.