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QUANTITATION OF CARBOHYDRATE DEFICIENT TRANSFERRIN IN HIGH ALCOHOL CONSUMPTION BY HPLC
QUANTITATION OF CARBOHYDRATE DEFICIENT TRANSFERRIN IN HIGH ALCOHOL CONSUMPTION BY HPLC
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机译:高效液相色谱法定量分析高醇消耗量中的碳水化合物缺乏铁传递蛋白
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摘要
A method for determining the amount of carbohydrate deficient transferrin (CDT) in blood serum involves saturating a sample of the blood serum with iron to provide isoforms of transferrin, separating the isoforms of transferrin from other serum proteins in the sample, and developing a chromatogram which relates the separated isoforms with different pI values. The separation step is preferably carried out in an ion exchange column using a salt gradient and the chromatogram is preferably developed using a high performance liquid chromatograph (HPLC). The method is particularly useful for identifying heavy alcohol consumption in a person, which is related to isoforms of transferrin having pI values of 5.9 and 5.7.
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