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NOVEL BONE AND PROSTATE-DERIVED PROTEIN FACTORS AFFECTING PROSTATE CANCER GROWTH, DIFFERENTIATION, AND METASTASIS
NOVEL BONE AND PROSTATE-DERIVED PROTEIN FACTORS AFFECTING PROSTATE CANCER GROWTH, DIFFERENTIATION, AND METASTASIS
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机译:影响前列腺癌生长,分化和转移的新型骨和前列腺蛋白质因子
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摘要
The role for a substantially purified human growth factor preparation is shown to contain a distinct polypeptide with apparent M. sub.r on SDS/PAGE of about 220 kD, and to be distinct from bFGF, with a most active fraction at about 220 kD. A human growth factor polypeptide of 157 kD was identified, in human bone marrow aspirates and from bone stromal cells, by immunoblotting with the mAb MS 329, and by affinity isolation using a MS 329 antibody column. A PSA stimulating autocrine factor, PSAF, that is precipitable in ammonium sulfate at between 60-80% saturation is able to induce PSA expression and secretion, and serves as an indicator of androgen independent prostate cell growth.
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