5,7-DIHYDROXY-2-METHYL-8-4-(3-HYDROXY-1)-(1-PROPYL)PIPERIDINYL-4H-1-BENZOPYRAN-4-ONE OR ITS STEREOISOMERS OR PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITIVE SALTS AND A METHOD OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry. SUBSTANCE: products: 5,7-dihydroxy-2-methyl-8-[4-(3-hydroxy-1)-(1-propyl)- piperidinyl]-4H-1-benzopyran-4-one of the formula (I) or its stereoisomers or pharmacologically acceptable acid-additive salts. Reagent 1: compound of the formula (II) where R₁ - metyl or acetyl. Reagent 2: cyanogen bromide. Reagent 3: diluted mineral acid or diluted alkaline metal hydroxide. Reagent 4: n-propylhalogenide. Reaction condition: in organic solvent medium. Synthesized compounds were used in medicine as antiinflammatory agents. EFFECT: improved method of synthesis. 4 cl, 2 tbl