3-AMINOPYRIDAZINE DERIVATIVES OR THEIR ACID-ADDITIVE PHARMACEUTICALLY ACCEPTABLE SALTS, INTERMEDIATE COMPOUNDS, METHOD OF SYNTHESIS OF 3-AMINOPYRIDAZINE DERIVATIVES OR THEIR ACID-ADDITIVE PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry. SUBSTANCE: product: 3-aminopyridazine derivatives of the formula (I) where: R_v - (C₁ - C₄)-alkyl; R₆ - H or OH; Z - the group (CH₂)_n where: when n = 0 then T - group of the formula (IV) where p = 2-3, R - (C₁ - C₃)-alkyl; when n = 1 then T - group of the formula (V) where p' and p'' = 3-4; when n = 2 then T - group of the formula (VI) where p = 2-3, or their acid-additive pharmaceutically acceptable salts. Intermediate compounds of the formula where: R ^{- (C₁ - C₃)-alkoxy-group; R_v and Z - as indicated above, and pharmaceutical composition based on compounds of the formula (I). Compounds of the formula (I) were synthesized by interaction of amine of the formula (II) with compound of the formula (III) . When compound of the formula (I) is synthesized where R₆ - OH then intermediate compound of the formula (I) reacts with hydrogen halide acid. Synthesized compounds were used in pharmacy. EFFECT: improved method of synthesis. 7 cl, 3 tbl}