FIELD: peptide chemistry, biochemistry. SUBSTANCE: invention relates to bioactive peptides of the general formula: R-Glu-Leu-Lys-Pro-Leu-X-Glu-Val-Leu-Asn-Leu-R-CLu-Leu-Lys-Pro-Leu-X-Glu-Val-Leu-Asn-Leu-R′, where R - CH3CO-(Ac), Ac-Glu-, Ac-Glu-Glu-, Ac-Leu-Glu-Glu-, HCO-(Form), Form-Glu-, Form-Glu-Glu-, Form-Leu-Glu-Glu-, , -Glu-, -Glu-Glu-, -Leu-Glu-Glu-; n = 8-18; X - L-Glu, D-Glu; R′ - OMe or NH2. Proposed peptides are relatively short (11, 12, 13 and 14 amino acid residues) fragments of human IL-2. They were synthesized by chemical synthesis made of classic procedures in solution using maximal protection of multifunctional amino acids followed by deblocking and isolation as a free form by method. Peptides contain protective groups at molecule termini that increase peptide resistance against proteolysis and providing favorable conditions for necessary conformation making at their effect on the cells due to N- and C-terminal charges neutralization as it takes place in natural protein. Synthesized peptides are inducing agents and/or potentiating agents of growth-stimulating activity of macrophage in vitro, they show regenerative-repairing action in vivo and can be used in medicine for treatment diseases accompanying generalized macrophage activation (hepatitis, liver toxic damages, liver cirrhosis, skin wounds, burns, polytraumas, diabetes, and others). EFFECT: enhanced effectiveness of peptides.
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机译：领域：肽化学，生物化学。物质：本发明涉及通式为：R-Glu-Leu-Lys-Pro-Leu-X-Glu-Val-Leu-Asn-Leu-R-CLu-Leu-Lys-Pro-Leu-X-的生物活性肽Glu-Val-Leu-Asn-Leu-R'，其中R-CH 3 CO-（Ac），Ac-Glu-，Ac-Glu-Glu-，Ac-Leu-Glu-Glu -，HCO-（表单），Form-Glu-，Form-Glu-Glu-，Form-Leu-Glu-Glu-，<图像文件=“ 00000001.GIF” he =“ 6” id =“ imag0.1” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 24” />，<图像文件=“ 00000002.GIF” he =“ 6” id =“ imag0.2” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 24” />-Glu-，<图像文件=“ 00000003.GIF” he =“ 6” id =“ imag0.3” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 24” />-Glu -Glu-，<图像文件=“ 00000004.GIF” he =“ 6” id =“ imag0.4” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 24” />-Leu-Glu-Glu-; n = 8-18; X-L-Glu，D-Glu; R'-OMe或NH 2 。建议的肽是人IL-2的相对较短的片段（11、12、13和14个氨基酸残基）。它们是通过在溶液中使用经典方法进行的化学合成来合成的，其中最大程度地保护多功能氨基酸，然后通过方法解封闭和分离为游离形式。肽在分子末端包含保护基团，这些保护基团增加了肽对蛋白水解的抵抗力，并由于其在天然蛋白质中发生的N和C端电荷中和作用，为它们对细胞的作用提供了必要构象的有利条件。合成肽是体外巨噬细胞生长刺激活性的诱导剂和/或增强剂，它们在体内具有再生修复作用，可用于治疗伴随巨噬细胞活化（肝炎，肝毒性损害，肝硬化）的疾病，皮肤伤口，烧伤，多发伤，糖尿病等）。效果：增强肽的有效性。
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