LACTAM DIPEPTIDES SHOWING INHIBITING ACTIVITY WITH RESPECT TO HUMAN LEUKOCYTE ELASTASE, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula . Invention relates to the new derivatives of amides that are pyrido[3,4-b]indole-2-yl-acetamides of the formula (I) which are inhibitors of human leukocyte elastase. Invention involves also intermediate compounds that can be useful for synthesis of indicated amide derivatives, methods of synthesis of amide derivatives, pharmaceutical compositions containing indicated amide derivatives and methods of their use. Synthesized compounds can be used as a tool in pharmacological, diagnostic studies, for treatment of diseases in mammalian where elastase takes part. EFFECT: improved method of synthesis, enhanced inhibiting activity.