A method for the production of (-) - (2r, 3s) - 2,3 - epoxy - 3 - (4 - methoxyphenyl) propionate - methyl ester.

摘要

Method of preparation of (-) - (2r, 3s) - 2,3 - epoxy - 3 - (4 - 4-methoxyphenyl) methyl propionate. & br / in an initial mixture containing the dextrorotatory and the levo-rotatory enantiomer of the trans - 2,3 - epoxy - 3 - (4 - 4-methoxyphenyl) methyl propionate, the dextro-rotatory enantiomer to transesterification in an anhydrous medium, in the presence of an enzyme which does not affect the levo-rotatory enantiomer. & br / the latter is a synthesis intermediate compounds such as diltiazem.