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Dry and Porous galenic form based on plants, its method of preparation and its applications

机译:基于植物的干燥和多孔盖伦形式,其制备方法及其应用

摘要

Solid compositions based on plants, capable of being converted to a dry and porous galenic form (lyophilized or equivalent form) which is undivided or powdered. Said dry and porous galenic form comprises a solid composition II consisting ofPPa solid composition I composed of:PP(A) one or more of the plants' active principles included in a homogeneous suspension of fresh or dry plants obtained by (a) cleaning and/or drying of the plant or part of the plant, (b) cryocomminution at a temperature below 0 C. until a particle size of less than about 100 m is obtained, (c) immersion of the particles for a suitable time in at least one appropriate solvent, (d) separation of the liquid phase and the solid phase of the suspension obtained, (e) expression of the solid phase obtained in (d) by cold pressing, and (f) mixing of the liquid phase obtained in (d) and the expressed liquid obtained in (e), andPP(B) at least one absorption promoter with a sequestering action,PPsaid mixture (A+B) being dried by removal of the solvent; andPP (C) at least one absorption promoter selected from surfactants,P Psaid composition II being lyophilized and optionally associated with excipients which are suitable from a pharmaceutical point of view.
机译:基于植物的固体组合物,能够转化为干燥的和多孔的盖伦形式(冻干或等效形式),该形式未分开或制成粉末。所述的干燥和多孔的盖伦化合物形式包括由以下组成的固体组合物II:由以下组成的固体组合物I:(P)(P)的一种或多种植物的活性成分包含在一种或多种植物的均质悬浮液中。通过(a)清洁和/或干燥植物或植物的一部分而获得的新鲜或干燥植物,(b)在低于0°C的温度下冷冻粉碎直至获得小于约100 m的粒径,(c)将颗粒在至少一种合适的溶剂中浸渍合适的时间,(d)分离得到的悬浮液的液相和固相,(e)通过冷压表达在(d)中得到的固相,和(f)将在(d)中获得的液相和在(e)中获得的所表达的液体与至少一种具有螯合作用的吸收促进剂混合,

通过除去溶剂干燥混合物(A + B); (C)至少一种选自表面活性剂的吸收促进剂,所述组合物II被冻干并且任选地与从药学观点来看合适的赋形剂结合。

著录项

  • 公开/公告号US5527783A

    专利类型

  • 公开/公告日1996-06-18

    原文格式PDF

  • 申请/专利权人 LABORATOIRES ARDEVAL;

    申请/专利号US19940231997

  • 发明设计人 GUY DERRIEU;BERNARD RAYNIER;

    申请日1994-04-21

  • 分类号A61K31/715;A61K31/705;A61K35/78;

  • 国家 US

  • 入库时间 2022-08-22 03:38:26

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