B it is to crowd, refinement method of protein Rib and that protein which are the cell surface protein which gives the immunity for many strains of the micrococcus, the medicine kit and the medicine composition

摘要

This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.