NEW TRITERPENOID SAPONINS AND THERAPEUTIC AGENT, HAVING AXIS-CYLINDER PROCESS ELONGATING ACTION AND COMPRISING THE SAME AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To obtain the subject new compound, which is a physiologically active substance, comprising specific triterpenoid saponins, having axis-cylinder process elongating actions and useful as an active ingredient, etc., of a therapeutic agent for Alzheimer type senile dementia, sequelae, etc., to cerebral apoplexy. ;SOLUTION: The new triterpenoid saponins are represented by the formula (R is a saccharide chain of an oleanolic acid glycoside). The saccharide chain of the oleanolic acid glycoside comprises Ara, Rha and Xyl and is useful as a physiologically active substance having axis-cylinder process elongating actions for an antidement agent for Alzheimer type senile dementia and a therapeutic agent, etc., of sequelae to cerebral apoplexy. The new physiologically active substance is obtained by drying the whole herb of Triplostegia grandifora Gagnep., belonging to the family Dipsacaceae and naturally growing in Szechwan Province in China, then extracting the dried whole herb with a 95% ethanol, distilling away the solvent in the extracted solution and treating the resultant dark brown solid by centrifugal liquid-liquid partition chromatography using a solvent comprising chloroform/methanol/isopropyl alcohol/water.;COPYRIGHT: (C)1997,JPO