LEUKEMIA CELL PROLIFERATION INHIBITING AGENT CONTAINING ANTISENSE OLIGONUCELOTIDE DERIVATIVE AGAINST WILMS TUMOR GENE (WT1)

摘要

PROBLEM TO BE SOLVED: To obtain a leukemia cell proliferation inhibiting agent containing an antisense oligonucleotide derivative. ;SOLUTION: This agent contains an antisense oligonucleotide derivative of the formula (X is O, S, a lower alkyl, a primary amine or a secondary amine; Y is O or S; Z is H or OH; B is adenine, guanine, thymine or cytosine when Z is H and is adenine, guanine, uracil or cytosine when Z is OH; R is H, dimethoxytrityl or a lower alkyl; (n) is 7-28) against a Wilms tumor gene (WT1). The antisense oligonucleotide derivative is e.g. a substance against WT1 of e.g. the transcription capping site, translation initiation region, exon or intron. It is administered by oral administration, intramuscular injection, intraperitoneal administration, endodermic injection, subcutaneous injection, intravenous infusion, introarterial infusion, intrarectal administration, etc.;COPYRIGHT: (C)1997,JPO