karuborin derivative

摘要

PURPOSE: To provide the new compound having excellent cholecystokinin antagonistic activity and pancreatic juice secretion-inhibitory activity, useful as a preventive or medicine for digestive organ-related diseases such as pancreatic lesions or gastrointestinal diseases. ;CONSTITUTION: The compound of formula I (R¹ is H, an alkyl, alkoxy or OH; R⁵ is H or combined with R¹ into alkylenedioxy; R² is H, a halogen, alkoxy or OH; R³ is H, an alkyl, carboxyalkyl, etc.; R⁴ is H, an alkyl, carboxyalkyl, aralkyl, formyl, etc.; n is 0-2) and a pharmacologically permissible salt thereof, e.g. 3-[9H-pirido(3,4-b)-indole-3-yl-carbonyl]amino-3-methyl-1-phenyl-2-indolinone. The compound of the formula I can be obtained by reaction between an amine compound of formula II or a salt thereof and a carboxylic acid compound of formula III, a reactive derivative therefrom or a salt thereof.;COPYRIGHT: (C)1994,JPO&Japio