TISSUE ACTIVATOR OF PLASMINOGEN, PROCESS OF ITS PREPARATION, DNA CHAIN BEING A CODE FOR THE TISSUE ACTIVATOR, PROCESS FOR PREPARING PLASMIDS AND PHARMACEUTICAL PREPARATION EXHIBITING FIBRINOLYTIC ACTIVITY

摘要

The present invention relates to a t-PA plasminogen tissue transporter which is not glycosylated and is constituted by a certain amino acid chain represented by formula I. For this chain, the DNA sequence is the DNA sequence represented by formula II. The activator is particularly suitable for use in the dissolution of blood clots and forms an active ingredient in a fibrinolytic pharmaceutical composition which is also part of the process, as well as the process for producing t-PA, the codon-containing plasmids for the same, and the process for producing such plasmids.ŕ