DERIVATIVE OF PLASMINOGEN TISSUE ACTIVATOR, CODE CHAIN, PROCESS FOR PREPARING SUCH DERIVATIVE, PROCESS FOR PREPARING PLASMID AND PREPARATION FOR DISSOLVING THROMBI

摘要

The present invention provides a tissue plasminogen activator derivative, t-PA with a non-glycosylated amino acid chain, a DNA strand that is a coding sequence for the derivative, a method of producing a plasmid for expressing the derivative thereof with its coding sequence, and a method for producing a t-PA derivative using a plasmid. the codon content of said derivative. The solution also includes a means for dissolving blood clots which contains said derivative as its active ingredient.ŕ