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Process for the preparation of semi-synthetic glycosaminoglycans with heparin or heparan structure modified at the 2-position of alpha-L-iduron-2-O-sulfate acid
Process for the preparation of semi-synthetic glycosaminoglycans with heparin or heparan structure modified at the 2-position of alpha-L-iduron-2-O-sulfate acid
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机译:制备具有在α-L-艾杜糖-2-O-硫酸的2-位修饰的肝素或乙酰肝素结构的半合成糖胺聚糖的方法
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摘要
A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III CHEM with heparin or heparan structure modified in position 2 of the alpha -L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic radical is described. Said process is carried out by treating glycosaminoglycans with heparin or heparan structure by means of a nucleophilic agent in alkaline medium.
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