AZACYCLOALKANE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS AND POULTRY FEED STUFFS CONTAINING THEM

摘要

Cholesterol and ergosterol biosynthesis inhibiting compounds of the formula R2R1 R3R4 N R8 (C)n(CH2)m YCN XAR10(I) R5R6 W1W2(CH2)p R7R9 (wherein: n denotes the numbers 0 or 1; m denotes the numbers 1 or 2; p denotes the numbers 0 or 1; A denotes a single bond, a straight-chain or branched C1-17-alkylene, C217-alkenylene or C2-4-alkynylene group; W1 and W2 each denotes a hydrogen atom or W1 and W2 together denote a carbon- carbon bond; X denotes a carbonyl or sulphonyl group with the proviso that where A denotes a bond and R10 denotes a hydrogen atom then X denotes a carbonyl group; Y denotes an oxygen or sulphur atom or an LNR11 group; R1, R2, R3, R4, R5 and R6 each denotes a hydrogen atom, or one, two or three of the groups R1, R2, R3, R4, R5 and R6, independently denote an alkoxycarbonyl group, or a straight-chain or branched C1-4-alkyl group optionally substituted by a hydroxy, alkoxy, alkylthio or dialkylamino group or by a phenyl group itself optionally substituted by a halogen atom or an alkyl group, and of the groups R1, R3 and R5 one, two or three may also denote a phenyl group optionally substituted by an alkyl group or a halogen atom, and the remaining groups of groups R1, R2, R3, R4, R5 and R6 each denote a hydrogen atom; R7 denotes a hydrogen or halogen atom, or an alkyl or alkoxy group; R8 and R9 independently denote a hydrogen atom or an alkyl group; R10 denotes a hydrogen atom, a C3-6-cycloalkyl group, a phenyl group optionally substituted by a halogen atom, by a straight-chain or branched C1-4-alkyl group, by a trifluoromethyl, alkoxy, cyano, nitro, alkylsulphonyl, or phenyl group, by two trifluoromethyl groups, by two to five halogen atoms, or by a halogen atom and an alkyl group optionally substituted by a fluorine atom, or R10 denotes a pyridyl group or a thienyl group optionally substituted by a halogen atom or by an alkyl group; and R11 denotes a hydrogen atom or an alkyl group; wherein, unless otherwise stated, each alkyl or alkylene moiety contains 1 to 3 carbon atoms and each halogen atom is a fluorine, chlorine or bromine atom) and the isomers, and salts thereof.