Trisubstituerte pyrimido £5,4-d pyrimidiner for modulering av multimedikamentresistens, legemidler som inneholder disse forbindelser og fremgangsmåter ved fremstilling av dem

摘要

The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula IMAGE (I) (wherein Ra, Rb and Rc are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the physiologically acceptable salts thereof, which have, inter alia, valuable pharmacological properties, particularly in chemotherapy a sensitizing effect on resistant tumors, the use thereof and processes for preparing them.