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SEMI-SYNTHETIC GLYCOSAMINOGLYCANES WITH HEPARIN OR HEPARIN STRUCTURE, WHICH CONTAIN ALPHA-L-IDURONIC ACID 2-0-SULFATE, MODIFIED IN 2-POSITION
SEMI-SYNTHETIC GLYCOSAMINOGLYCANES WITH HEPARIN OR HEPARIN STRUCTURE, WHICH CONTAIN ALPHA-L-IDURONIC ACID 2-0-SULFATE, MODIFIED IN 2-POSITION
The synthesis of new semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha -L-iduronic-2-O-sulfate acid modified in position 2 is described in which the sulfate group is, entirely or in part, substituted with a nucleophilic radical. These new semi-synthetic glycosaminoglycans of general formula IV CHEM have good pharmaceutical properties in that they may also be absorbed orally and have good anti-thrombotic activity accompanied by low risk of haemorrhage and reduced anti-coagulating activity.
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