Method of synthesising semi-synthetic glycosaminoglycans with heparin or heparin structures containing 2-position modified alpha-L-iduroic acid-2-O-sulphate

摘要

A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III CHEM with heparin or heparan structure modified in position 2 of the alpha -L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic radical is described. Said process is carried out by treating glycosaminoglycans with heparin or heparan structure by means of a nucleophilic agent in alkaline medium.