Semi-synthetic glycosaminoglycans with a heparin or heparin structure, but which contain 2-position modified alpha-L-iduronic acid 2-0 sulfate

摘要

The synthesis of new semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha -L-iduronic-2-O-sulfate acid modified in position 2 is described in which the sulfate group is, entirely or in part, substituted with a nucleophilic radical. These new semi-synthetic glycosaminoglycans of general formula IV CHEM have good pharmaceutical properties in that they may also be absorbed orally and have good anti-thrombotic activity accompanied by low risk of haemorrhage and reduced anti-coagulating activity.