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VARIANTS OF TISSUE PLASMINOGEN ACTIVATOR WITH IMPROVED THERAPEUTIC EFFECT
VARIANTS OF TISSUE PLASMINOGEN ACTIVATOR WITH IMPROVED THERAPEUTIC EFFECT
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机译:改善组织疗效的组织型纤溶酶原激活剂
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摘要
The invention concerns tissue plasminogen activator (t-PA) variants which are glycosylated at any of positions 103-105, and are devoid of functional carbohydrate structure at position 117 of wild-type human t-PA amino acid sequence. The variants have extended circulatory half-life and substantially retained fibrin binding, or improved in vivo fibrinolytic potency, as compared to wild-type human t-PA. IMAGE
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