NUCLEOTIDE CODING SEQUENCE FOR A PROTEIN OF THE EXTERNAL MEMBRANE OF NEISSERIA MENINGITIDIS, AND ITS USE IN THE PREPARATION OF VACCINES.

摘要

THE CURRENT INVENTION IS RELATED TO A METHOD FOR THE ISOLATION OF A NUCLEOTIDE SEQUENCE CODING A PROTEIN PROVIDED WITH MOLECULAR WEIGHT AROUND 64,000 DALTONS, LOCATED IN THE EXTERNAL MEMBRANE OF THE N. MENINGITIDIS, AS WELL AS THE RECOMMENDED DNA , WHICH IS USED FOR THE TRANSFORMATION OF A GUEST MICROORGANISM. THE TECHNICAL OBJECT PURSUED WITH THE INVENTION IS THE IDENTIFICATION OF THE CODING OF A NUCLEOTIDE SEQUENCE FOR A COMMON AND HIGHLY PRESERVED PROTEIN OF MOST OF THE NEISSERIA PATHOGENIC EFFORTS, THE PRODUCTION OF THIS PROTEIN WITH A HIGH LEVEL OF PURE OF TOOLS, USING THE SHAPE OF THE RECOMBINANT, SO THAT IT CAN BE USED IN DIAGNOSTIC METHODS AND PREPARED FOR VACCINES WITH A WIDE IMMUNOPROTECTION SPECTRUM.