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NUCLEOTIDE SEQUENCE CODING FOR AN OUTER MEMBRANE PROTEIN FROM NEISSERIA MENINGITIDIS AND USE OF SAID PROTEIN IN VACCINE PREPARATIONS
NUCLEOTIDE SEQUENCE CODING FOR AN OUTER MEMBRANE PROTEIN FROM NEISSERIA MENINGITIDIS AND USE OF SAID PROTEIN IN VACCINE PREPARATIONS
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机译:猪奈瑟氏球菌外膜蛋白的核苷酸序列编码及赛义德蛋白在疫苗制备中的应用
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摘要
The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64 000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum. IMAGE
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