DE-N-ACETYL-SYALIC ACID AND THEIR APPLICATIONS AS MODIFIERS OF CELL PHYSIOLOGY

摘要

Substantially pure gangliosides containingde-N-acetyl-sialic acid. A culture medium forstimulating growth of human and animal cellscomprising: (1) essential nutrients for cell growth,and (2) a cell growth stimulatory amount of one ormore gangliosides containing de-N-acetyl-sialic acid.A method for stimulating growth of human and animalcells cultured in vitro comprising contacting saidcells in culture with a cell growth stimulatory amountof one or more gangliosides containingde-N-acetyl-sialic acid. A medicament for stimulatinggrowth of human and animal cells comprising: (1) acell growth stimulatory amount of one or more growthstimulators selected from the group consisting ofgangliosides containing de-N-acetyl-sialic acid,substances that promote synthesis of gangliosidescontaining de-N-acetyl-sialic acid and pharmaceuticallyacceptable salts thereof: and (2) a pharmaceuticallyacceptable carrier, diluent or excipient. A method forstimulating growth of human and animal cells in vivocomprising contacting said cells with a cell growthstimulatory amount of gangliosides containingde-N-acetyl-sialic acid, substances that promotesynthesis of gangliosides containing de-N-acetyl-sialicacid, and pharmaceutically acceptable salts thereof. Amedicament for inhibiting growth of human and animalcells comprising: (1) a cell growth inhibitory amountof one or more growth inhibitors that block synthesisof gangliosides containing de-N-acetyl-sialic acid orpharmaceutically acceptable salts thereof; and (2) apharmaceutically acceptable carrier, diluent orexcipient. A method for inhibiting growth of humanand animal cells in vivo comprising contacting saidcells with a cell growth inhibitory amount of one ormore growth inhibitors that block synthesis ofgangliosides containing de-N-acetyl-sialic acid orpharmaceutically acceptable salts thereof.