N,N'-DI(ARALKYL) N,N'-DI(CARBOXYALKYL) ALKYLENE DI- OR TRIAMINE AND N-(ARALKYL) N'-(CARBOXYALKYL) N,N'-DI(CARBOXYALKYL) ALKYLENE DI- OR TRIAMINE DERIVATIVES AND THEIR USE IN PHARMACEUTICAL OR COSMETIC APPLICATIONS

摘要

Novel derivatives of N, N'-di (aralkyl) -N, N'-di (carboxyalkyl) alkylene di- or triamine and N- (aralkyl) -N '- (carboxyalkyl) -N, N'-di (carboxyalkyl) alkylene di - or triamine. These derivatives correspond to the following general formula: (I) in which: n is 0, 1 or 2, m and p are 1, 2 or 3, R, R1, R2, R3 and R4, identical or different, represent an atom of hydrogèneou an alkyl radical, linear or branched C1-C4 R1 and R2 or R2 and R3 taken together may form a 5- or 6-membered ring, X represents a radical -COOR 4, or the radical of formula: X represents a radical -COOR 4, or the radical of formula (i) or the radical of formula: (ii) in the latter case when p is 1, Z1, Z2 and Z3, identical or different, represent a hydrogen atom, an alkyl radical, linear or branched C1-C4 radical -OR5 or -NR5R'5 R5 and R'5 represents a hydrogen atom or an alkyl radical, linear or branched C1-C4 alkyl, provided that when n = 0, m = 1 and X is -COOR 4 or the radical of formula (ii) at least one of R, R1 or R2 is other than hydrogen, and their salts and metal complexes. Use in pharmaceutical and cosmetic compositions for protecting the body against oxidative stress situations associated with certain pathological states.